Mexico has extradited 29 alleged drug cartel members to the United States – including high-profile gang leaders.

Those extradited include notorious drug lord Rafael Caro Quintero who has been wanted by the US for the murder of an American agent 40 years ago.

The move – considered to be of the biggest extraditions in Mexico’s history – is seen as a major step in bilateral security relations between the two countries.

It comes after US President Donald Trump threatened earlier this year to impose tariffs on imports from Mexico, accusing it of failing to tackle drug trafficking and mass migration.

“As President Trump has made clear, cartels are terrorist groups, and this Department of Justice is devoted to destroying cartels and transnational gangs,” US Attorney General Pam Bondi said in a statement on Thursday night.

“We will prosecute these criminals to the fullest extent of the law in honour of the brave law enforcement agents who have dedicated their careers – and in some cases, given their lives – to protect innocent people from the scourge of violent cartels,” she added.

Reacting to Caro Quintero’s extradition DEA Acting Administrator Derek Maltz hailed the move as a “victory for the Camarena family”.

He added: “Today sends a message to every cartel leader, every trafficker, every criminal poisoning our communities: You will be held accountable.

“No matter how long it takes, no matter how far you run, justice will find you.”

Quintero is expected to appear in court in New York on Friday.

Other fugitives extradited include the founders of the brutal Zetas Cartel – Miguel Angel Treviño and his brother Omar Treviño.

Known as Z-40 and Z-42 respectively, the two men ran the feared organisation for years before its eventual demise in the mid 2010s.

Miguel Treviño, who was arrested by Mexican marines in July 2013, was wanted on both sides of the border for ordering massacres and running drugs on a global scale.

Omar Treviño – who was wanted in the US and Mexico on charges of drug trafficking, kidnap and murder – was captured by security forces in Monterrey in March 2015.

Their criminal empire spanned a wide range of illicit activities including cocaine-smuggling, people trafficking, extortion, gun-running and kidnappings.

Police in Webb County, Texas, confirmed the brothers extradition and warned Americans from crossing into Mexico for fear of reprisals.